Ruthenium-carbohydrate conjugates as cytostatic drugs with an enhanced selectivity to cancer cells

Duration: 
01.01.2017 - 31.12.2019
Classification
Grant agency: 
GACR
Grant type: 
Standardní projekt
Registration number: 
17-05838S
Investigators
Internal investigator/coinvestigator: 
Karban Jindřich
Internal investigator: 
is coinvestigator only
External investigator/coinvestigator: 
Jiří Pinkas, J. Heyrovsky Institute of Physical Chemistry CAS and Roman Hrstka, Masaryk Memorial Cancer Institute
Annotation: 

Cancer cells frequently display an order higher d-glucose uptake in comparison to normal ones (Warburg effect). Accordingly, cancer cells express higher levels of glucose and other monosaccharide transporters in the cytoplasmic membrane. The project goal is to develop organometallic cytotoxic species profiting from Warburg effect and displaying enhanced efficacy for cancer cell lines. The series of ruthenium-carbohydrate conjugates will be prepared and the effect of the carbohydrate on cytotoxicity, transport, and selectivity will be investigated.